Description

2,3-Dihydro-α-(Trifluoromethyl)-1H-Indole-2-Propanoic Acid is a high-value, fluorinated indole derivative that serves as a critical advanced pharmaceutical intermediate (API). This compound matters for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas where the trifluoromethyl group enhances metabolic stability and bioavailability. Pharmaceutical research and development organizations, as well as fine chemical manufacturers, need this high-purity building block to accelerate their drug discovery and process development pipelines.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of novel drug candidates, especially in neurology and psychiatry.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the construction of complex molecules for preclinical and clinical development.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial manufacturing of APIs.
• Biochemical Research: Potential use as a tool compound or probe in biochemical assays and target validation.
• Fine Chemical Production: A building block for other specialty chemicals requiring the indole-trifluoromethyl motif.

Basic Information

Product Name	2,3-Dihydro-α-(Trifluoromethyl)-1H-Indole-2-Propanoic Acid
CAS No.	690632-19-0
Molecular Formula	C₁₂H₁₀F₃NO₂
Molecular Weight	257.21 g/mol
Synonyms	2-(2,3-Dihydro-1H-indol-2-yl)-3,3,3-trifluoropropanoic acid; α-(Trifluoromethyl)-1H-indole-2-propanoic acid, 2,3-dihydro-; 2,3-Dihydro-α-(trifluoromethyl)-1H-indole-2-propionic acid; 2-(Indolin-2-yl)-3,3,3-trifluoropropanoic acid; Trifluoromethyl indoline propanoic acid; 690632-19-0; (2,3-Dihydro-1H-indol-2-yl)-3,3,3-trifluoropropanoic acid
EINECS	Contact for details

Quality Control

Our 2,3-Dihydro-α-(Trifluoromethyl)-1H-Indole-2-Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with complete traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.