Description

1H-Benzimidazole, 2-(Chloromethyl)-4,5,6,7-Tetrahydro- is a versatile bicyclic heterocyclic compound featuring a chloromethyl substituent on a partially saturated benzimidazole core. This specific molecular architecture makes it a valuable pharmaceutical intermediate and a key building block in organic synthesis. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used as a building block for developing advanced fungicides, herbicides, and insecticides, leveraging the bioactive benzimidazole scaffold.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for metal catalysis and in the synthesis of organocatalysts for asymmetric synthesis.
• Material Science Research: Acts as a monomer or functionalizing agent in the development of advanced polymers, dyes, and organic electronic materials.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme function and biological pathways due to its ability to mimic structural motifs found in biomolecules.

Basic Information

Product Name	1H-Benzimidazole, 2-(Chloromethyl)-4,5,6,7-Tetrahydro-
CAS No.	685822-11-1
Molecular Formula	C8H11ClN2
Molecular Weight	170.64 g/mol
Synonyms	2-(Chloromethyl)-4,5,6,7-tetrahydro-1H-benzimidazole; 4,5,6,7-Tetrahydro-2-(chloromethyl)-1H-benzimidazole; 2-(Chloromethyl)-4,5,6,7-tetrahydrobenzimidazole; Tetrahydro-2-(chloromethyl)benzimidazole
EINECS	Contact for details

Quality Control

Our production of 1H-Benzimidazole, 2-(Chloromethyl)-4,5,6,7-Tetrahydro- adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent composition. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with agreed specifications. For custom synthesis or specific pharmacopeial standards (e.g., USP, EP), please contact our technical team to discuss your requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.