Description

(5-Bromo-4-Chloropyrrolo[2,3-B]Pyridin-1-Yl)-Tri(Propan-2-Yl)Silane is a high-purity, organosilicon-protected heterocyclic building block designed for advanced synthetic chemistry. This compound is critical for researchers and process chemists requiring precise functionalization and stability in sensitive reaction sequences. It is primarily utilized in the pharmaceutical and agrochemical industries for the development of novel active ingredients, particularly in cross-coupling reactions and as a key intermediate in medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Serves as a protected, halogenated heterocyclic core for the synthesis of potential drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the pyrrolopyridine scaffold offers unique biological activity.
• Material Science Precursor: Acts as a specialized monomer or functionalizing agent for creating silicon-containing polymers or surface-modified materials.
• Cross-Coupling Reactions: The bromo and chloro substituents make it a valuable substrate for sequential Suzuki, Stille, or Buchwald-Hartwig amination reactions.
• Medicinal Chemistry SAR Studies: The triisopropylsilyl (TIPS) protecting group allows for selective deprotection and further elaboration, facilitating structure-activity relationship exploration.
• Chemical Biology Probes: Can be incorporated into molecular probes for studying biological targets and pathways.

Basic Information

Item	Detail
Product Name	(5-Bromo-4-Chloropyrrolo[2,3-B]Pyridin-1-Yl)-Tri(Propan-2-Yl)Silane
CAS No.	685513-96-6
Molecular Formula	C17H25BrClN2Si
Molecular Weight	418.84 g/mol
Synonyms	1-((Triisopropylsilyl)-5-bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-4-chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine, 1-(triisopropylsilyl)-; TIPS-5-Bromo-4-chloropyrrolo[2,3-b]pyridine; 1-Triisopropylsilyl-5-bromo-4-chloropyrrolo[2,3-b]pyridine; 685513-96-6; (5-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridin-1-yl)triisopropylsilane
EINECS	Contact for details

Quality Control

Our (5-Bromo-4-Chloropyrrolo[2,3-B]Pyridin-1-Yl)-Tri(Propan-2-Yl)Silane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for extended periods to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.