Description

1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid, 4-Fluoro-1-[Tris(1-Methylethyl)Silyl]-, Methyl Ester is a high-value, protected heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because its unique molecular architecture, featuring a fluorinated pyrrolopyridine core and a silyl protecting group, makes it a critical intermediate for constructing complex pharmacophores. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies to explore new chemical entities and optimize lead compounds.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial production scales.
• Custom Synthesis & Contract Manufacturing: A vital building block for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client pipelines.
• Agrochemical Research: Potential application in the synthesis of advanced, fluorinated active ingredients for crop protection.
• Material Science Exploration: Investigated as a monomer or precursor for creating specialty polymers and organic electronic materials.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid, 4-Fluoro-1-[Tris(1-Methylethyl)Silyl]-, Methyl Ester
CAS No.	685513-92-2
Molecular Formula	C18H25FN2O2Si
Molecular Weight	348.50 g/mol
Synonyms	4-Fluoro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester; Methyl 4-fluoro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate; 1-Triisopropylsilyl-4-fluoro-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester; 4-Fluoro-1-triisopropylsilyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester; TIPS-4-Fluoro-1H-pyrrolo[2,3-b]pyridine-5-carboxylate methyl ester; 685513-92-2; 1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid, 4-fluoro-1-[tris(1-methylethyl)silyl]-, methyl ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization using techniques including HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.