Description

(5R)-2,2,3-Trimethyl-5-Benzyl-4-Imidazolidinone is a chiral imidazolidinone derivative that serves as a high-value intermediate and catalyst in asymmetric synthesis. Its significance lies in its role as a key building block and organocatalyst for constructing enantiomerically pure compounds, which are critical for pharmaceutical and fine chemical development. This product is essential for research and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• Asymmetric Organocatalysis: Employed as a chiral catalyst or catalyst precursor in enantioselective organic transformations, such as aldol, Mannich, and Diels-Alder reactions.
• Pharmaceutical Intermediate: Serves as a crucial chiral building block in the synthesis of active pharmaceutical ingredients (APIs) for drugs targeting central nervous system disorders, cardiovascular diseases, and infectious diseases.
• Agrochemical Synthesis: Used in the development of enantiomerically pure herbicides, fungicides, and insecticides, where specific stereochemistry is required for optimal biological activity.
• Fine Chemical Production: A key intermediate for manufacturing specialty chemicals, flavors, and fragrances that demand high enantiomeric purity.
• Academic & Industrial R&D: A valuable reagent for method development and discovery chemistry in laboratories focused on stereoselective synthesis.

Basic Information

Product Name	(5R)-2,2,3-Trimethyl-5-Benzyl-4-Imidazolidinone
CAS No.	685128-77-2
Molecular Formula	C₁₃H₁₈N₂O
Molecular Weight	218.30 g/mol
Synonyms	(5R)-2,2,3-Trimethyl-5-benzylimidazolidin-4-one; (R)-2,2,3-Trimethyl-5-benzyl-4-imidazolidinone; 5-Benzyl-2,2,3-trimethyl-4-imidazolidinone, (5R)-; (R)-5-Benzyl-2,2,3-trimethylimidazolidin-4-one; MacMillan Catalyst Derivative; Chiral Imidazolidinone Catalyst; Organocatalyst Intermediate
EINECS	Contact for details

Quality Control

Our (5R)-2,2,3-Trimethyl-5-Benzyl-4-Imidazolidinone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, to ensure it meets the high-purity standards required for synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, confirming compliance with customer and industry requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain product stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.