Description

5-Bromo-2-(trifluoromethoxy)benzyl bromide is a high-value, multi-functional organic building block characterized by its reactive benzyl bromide and bromoaryl functional groups. This compound is essential for introducing the 5-bromo-2-(trifluoromethoxy)benzyl moiety into target molecules, enabling the synthesis of complex intermediates with unique physicochemical properties. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides, where the trifluoromethoxy and bromine groups contribute to biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and polymers due to its ability to modify electronic properties and introduce cross-linking sites.
• Custom Synthesis and Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke intermediates for client projects.

Basic Information

Product Name	5-Bromo-2-(Trifluoromethoxy)Benzyl Bromide
CAS No.	685126-87-8
Molecular Formula	C9H5Br2F3O
Molecular Weight	361.94 g/mol
Synonyms	1-(Bromomethyl)-5-bromo-2-(trifluoromethoxy)benzene; alpha,5-Dibromo-2-(trifluoromethoxy)toluene; (5-Bromo-2-(trifluoromethoxy)phenyl)methyl bromide; 2-(Trifluoromethoxy)-5-bromobenzyl bromide; 5-Bromo-2-(trifluoromethoxy)benzyl bromide; 5-Bromo-α-bromo-2-(trifluoromethoxy)toluene
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(trifluoromethoxy)benzyl bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support cGMP (current Good Manufacturing Practice) standards for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. Due to its light-sensitive nature and reactive benzyl bromide group, it is recommended to store under an inert atmosphere for long-term stability and to minimize decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.