Description

Perampanel is a high-purity, non-competitive AMPA receptor antagonist used as a key active pharmaceutical ingredient (API). Its primary value lies in its critical role in the formulation of advanced antiepileptic medications, offering a targeted mechanism of action for managing partial-onset seizures. This compound is essential for pharmaceutical manufacturers and research institutions engaged in the development and production of neurological therapeutics. Perampanel CAS NO 684648-40-6 represents a specialized chemical with stringent quality requirements for global pharmaceutical supply chains.

Application

• Pharmaceutical API: Primary use as the active ingredient in antiepileptic drug formulations for the treatment of partial-onset seizures.
• Neurological Research: Critical compound for in-vitro and in-vivo studies targeting AMPA glutamate receptors.
• Drug Development: Serves as a reference standard and building block in the R&D of new central nervous system (CNS) therapies.
• Generic Pharmaceutical Manufacturing: Used by manufacturers producing generic versions of antiepileptic medications.
• Clinical Trial Material: Supplied as a GMP-grade material for Phase I-III clinical studies.
• Analytical Standard: High-purity grade used for quality control, method development, and validation in analytical laboratories.

Basic Information

Product Name	Perampanel
CAS No.	684648-40-6
Molecular Formula	C23H15N3O
Molecular Weight	349.39 g/mol
Synonyms	2-(2-Oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile; Fycompa; E2007; AMPA Receptor Antagonist; (3S)-2-(2-Oxo-1-phenyl-5-(pyridin-2-yl)-1,2-dihydro-3H-pyridin-3-yl)benzonitrile; Perampanelum; Perampanelo
EINECS	Contact for details

Quality Control

Our Perampanel is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets pharmaceutical-grade specifications, including identity, purity, and impurity profile verification against relevant pharmacopeial standards. A Certificate of Analysis (COA) is provided with each shipment, detailing results for assay, related substances, residual solvents, and other critical parameters. We support compliance with cGMP, ICH Q7, and other international regulatory guidelines for API manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity ≤ 0.15%, Total impurities ≤ 0.5%
Water Content (KF)	≤ 0.5% w/w
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	-30.0° to -34.0° (c=1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.