Description

[2H7]-Ropivacaine is a deuterium-labeled analog of the widely used local anesthetic, Ropivacaine. This stable isotope-labeled compound is essential for advanced analytical and pharmacokinetic studies, providing critical internal standards for mass spectrometry. It is primarily utilized by pharmaceutical research and development teams, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism, bioanalytical method development, and clinical trial support.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference compound for the precise quantification of Ropivacaine in complex biological matrices like plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracing and measurement of Ropivacaine and its metabolites in absorption, distribution, metabolism, and excretion (ADME) studies.
• Bioanalytical Method Development and Validation: Used to develop, optimize, and validate highly sensitive and specific analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Clinical Trial Research: Supports the reliable bioanalysis of Ropivacaine levels in patient samples during Phase I-IV clinical trials.
• Forensic and Toxicological Analysis: Assists in the accurate identification and quantification of Ropivacaine in forensic investigations and toxicology reports.
• Pharmaceutical Quality Control: Can be employed in impurity profiling and stability-indicating assay methods for Ropivacaine drug substances and products.

Basic Information

Product Name	[2H7]-Ropivacaine
CAS No.	684647-62-9
Molecular Formula	C17H19D7N2O
Molecular Weight	277.45 g/mol
Synonyms	(S)-(-)-1-Propyl-2',6'-pipecoloxylidide-d7; (S)-1-Butyl-2',6'-pipecoloxylidide-d7 (deuterated form); Ropivacaine-d7; Ropivacaine (hexadeutero, monodeutero); Deuterated Ropivacaine; Naropin-d7 (labeled analog); (2S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide-d7
EINECS	Contact for details

Quality Control

Our [2H7]-Ropivacaine is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment, chemical purity (by HPLC), and identity confirmation (by NMR and MS). We adhere to relevant industry standards for stable isotope-labeled compounds to ensure batch-to-batch consistency and reliability for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥98 atom % D
Chemical Purity	≥95% (by HPLC)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.