Description

3,4-Thiophenediol, Tetrahydro-2-Mercapto-, (2R,3R,4R)-Rel- (9Ci) is a high-purity, stereochemically defined thiol derivative of tetrahydrothiophene, serving as a sophisticated chiral building block and ligand precursor in advanced synthetic chemistry. Its value lies in the precise spatial arrangement of its functional groups, enabling the synthesis of complex molecules with high stereoselectivity for critical applications in pharmaceuticals and materials science. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require enantiomerically pure intermediates for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in antiviral, anticancer, and central nervous system (CNS) therapeutic areas.
• Asymmetric Catalysis Ligand Precursor: Used to develop novel chiral ligands and organocatalysts for enantioselective synthesis, enhancing yield and purity in fine chemical production.
• Agrochemical Synthesis: Employed in the research and development of advanced, stereospecific pesticides and herbicides with improved efficacy and environmental profiles.
• Material Science Research: Serves as a functional monomer or cross-linking agent in the development of polymers with specific optical or electronic properties.
• Chemical Biology Probe Development: Utilized to create tagged molecules for studying protein interactions and enzyme mechanisms due to its reactive thiol group.
• Process Chemistry Optimization: Acts as a model compound for scaling up stereospecific synthetic routes from laboratory to pilot plant scale.

Basic Information

Item	Details
Product Name	3,4-Thiophenediol, Tetrahydro-2-Mercapto-, (2R,3R,4R)-Rel- (9Ci)
CAS No.	683278-61-7
Molecular Formula	C4H8OS2
Molecular Weight	136.23 g/mol
Synonyms	(2R,3R,4R)-Tetrahydro-2-mercapto-3,4-thiophenediol; rel-(2R,3R,4R)-Tetrahydro-2-mercapto-3,4-thiophenediol; Tetrahydro-2-mercapto-3,4-thiophenediol (rel-(2R,3R,4R)-form); 3,4-Dihydroxy-tetrahydrothiophene-2-thiol (stereoisomer); Chiral tetrahydrothiophenedithiol derivative
EINECS	Contact for details

Quality Control

Every batch of 3,4-Thiophenediol, Tetrahydro-2-Mercapto-, (2R,3R,4R)-Rel- (9Ci) is produced and controlled under a strict quality management system. Our products undergo rigorous quality testing, including chiral purity analysis by HPLC, to ensure compliance with exacting R&D and process chemistry standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with each shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) and easily oxidized nature, store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C). Keep the container in a cool, dry, and well-ventilated place, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.