Description

n-Boc-4-Hydroxy-3,4-Dihydro-1H-Isoquinoline CAS NO 681448-77-1 is a high-purity, protected heterocyclic building block essential for advanced organic synthesis. This compound is valued for its role as a key chiral intermediate in the development of complex pharmaceutical molecules, particularly in medicinal chemistry and drug discovery. It is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of bioactive compounds and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in the design and construction of complex molecular scaffolds for structure-activity relationship (SAR) studies.
• Asymmetric Synthesis: Serves as a versatile building block in stereoselective reactions to introduce the tetrahydroisoquinoline moiety.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of target molecules.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds or molecular probes for biological target identification.

Basic Information

Product Name	n-Boc-4-Hydroxy-3,4-Dihydro-1H-Isoquinoline
CAS No.	681448-77-1
Molecular Formula	C₁₄H₁₇NO₃
Molecular Weight	247.29 g/mol
Synonyms	tert-Butyl 4-hydroxy-3,4-dihydro-1H-isoquinoline-2(1H)-carboxylate; 4-Hydroxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; 2-Boc-4-hydroxy-1,2,3,4-tetrahydroisoquinoline; 4-Hydroxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid 1,1-dimethylethyl ester; N-Boc-4-hydroxy-1,2,3,4-tetrahydroisoquinoline; 1,1-Dimethylethyl 4-hydroxy-3,4-dihydro-1H-isoquinoline-2(1H)-carboxylate
EINECS	Contact for details

Quality Control

Our n-Boc-4-Hydroxy-3,4-Dihydro-1H-Isoquinoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to meet exacting research and development standards. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.