Description

1H-Indazole-7-Carboxylic Acid, Methyl Ester, Hydrochloride is a high-purity organic salt and a key synthetic intermediate in advanced pharmaceutical research and development. This compound is valued for its role as a versatile building block in the construction of complex heterocyclic molecules, particularly those targeting specific biological pathways. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly those containing the indazole scaffold, which is prevalent in kinase inhibitors and other therapeutic agents.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the indazole core can contribute to biological activity.
• Chemical Biology & Proteomics: Serves as a precursor for designing molecular probes and activity-based protein profiling (ABPP) reagents to study enzyme function.
• Material Science: Potential monomer or precursor for the synthesis of specialty polymers and advanced organic materials with specific electronic or photonic properties.
• Academic & Contract Research: Essential for medicinal chemistry programs in universities and Contract Research Organizations (CROs) exploring new chemical entities.
• Process Chemistry: Employed in route scouting and scale-up optimization for the commercial production of target molecules.

Basic Information

Product Name	1H-Indazole-7-Carboxylic Acid, Methyl Ester, Hydrochloride
CAS No.	677304-71-1
Molecular Formula	C9H9N2O2·HCl
Molecular Weight	212.64 g/mol (Free base: 177.18 g/mol)
Synonyms	7-Methoxycarbonyl-1H-indazole hydrochloride; Methyl 1H-indazole-7-carboxylate hydrochloride; 1H-Indazole-7-carboxylic acid methyl ester hydrochloride; Methyl 7-indazolecarboxylate hydrochloride; Indazole-7-carboxylic acid methyl ester HCl; 7-Carbomethoxyindazole hydrochloride; 7-(Methoxycarbonyl)-1H-indazole hydrochloride
EINECS	Contact for details

Quality Control

Our 1H-Indazole-7-Carboxylic Acid, Methyl Ester, Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF for moisture content, to ensure it meets the stringent requirements of research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.