Description

1-(6-Chloro-3-Indolyl)-2,2,2-Trifluoroethanone is a high-value trifluoromethyl ketone derivative of a chlorinated indole, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in providing a reactive carbonyl handle and a halogenated aromatic system, enabling the construction of complex molecules for pharmaceutical and agrochemical research. This compound is primarily needed by R&D chemists and process development scientists in the life sciences sector for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides that leverage the indole and trifluoromethyl motifs for enhanced bioactivity.
• Material Science Precursor: Serves as a monomer or functionalizing agent for creating specialty polymers and organic electronic materials.
• Chemical Biology Probe Development: Utilized in crafting molecular probes and inhibitors for studying enzyme mechanisms and biological pathways.
• Fluorine Chemistry: A valuable substrate for exploring new fluorination reactions and synthesizing other trifluoromethyl-containing compounds.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and discovery chemistry projects.

Basic Information

Product Name	1-(6-Chloro-3-Indolyl)-2,2,2-Trifluoroethanone
CAS No.	676477-10-4
Molecular Formula	C10H5ClF3NO
Molecular Weight	247.60 g/mol
Synonyms	6-Chloro-1H-indol-3-yl trifluoromethyl ketone; 6-Chloro-3-(trifluoroacetyl)indole; 2,2,2-Trifluoro-1-(6-chloro-1H-indol-3-yl)ethanone; 1-(6-Chloro-1H-indol-3-yl)-2,2,2-trifluoroethanone; 6-Chloro-3-trifluoroacetylindole; 6-Chloroindole-3-carboxylic acid trifluoromethyl ketone; 3-Trifluoroacetyl-6-chloroindole
EINECS	Contact for details

Quality Control

Our 1-(6-Chloro-3-Indolyl)-2,2,2-Trifluoroethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under inert atmosphere where appropriate to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.