Description

4-Bromoindole-1-Carboxylic Acid tert-Butyl Ester is a versatile and high-purity brominated indole derivative, serving as a critical protected intermediate in advanced organic synthesis. Its value lies in enabling the efficient construction of complex heterocyclic scaffolds, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality building blocks for drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel indole-based active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and combinatorial chemistry libraries to explore new therapeutic agents.
• Agrochemical Synthesis: Intermediate in the development of new crop protection agents and pesticides with indole core structures.
• Fine Chemical Production: Serves as a precursor for specialty chemicals, dyes, and advanced materials requiring functionalized indole units.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological development and the synthesis of complex natural product analogs.

Basic Information

Product Name	4-Bromoindole-1-Carboxylic Acid tert-Butyl Ester
CAS No.	676448-17-2
Molecular Formula	C13H14BrNO2
Molecular Weight	296.16 g/mol
Synonyms	1-Boc-4-bromoindole; 4-Bromo-1H-indole-1-carboxylic acid, 1,1-dimethylethyl ester; tert-Butyl 4-bromo-1H-indole-1-carboxylate; 4-Bromoindole-1-carboxylic acid tert-butyl ester; 4-Bromo-1-(tert-butoxycarbonyl)indole; 1-tert-Butoxycarbonyl-4-bromoindole; 4-Bromo-1-Boc-indole; 4-Br-1H-indole-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 4-Bromoindole-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with full batch-specific data are provided to guarantee consistency and traceability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.