Description

Spiro[3H-Indole-3,3-Pyrrolidin]-2(1H)-One, 2-Ethyl-, (2R,3R)-Rel- (9Ci) is a high-purity, chiral spirocyclic indole derivative of significant interest in advanced organic synthesis. This compound serves as a sophisticated pharmaceutical intermediate and a versatile building block for constructing complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncological targets.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel drug candidates, especially those targeting neurological disorders.
• Asymmetric Synthesis Building Block: Utilized in stereoselective reactions to introduce complex spirocyclic frameworks into target molecules.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and hit-to-lead optimization programs.
• Process Chemistry Development: Serves as a starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Chemical Reference Standard: Used for analytical method development, validation, and quality control in API manufacturing.
• Academic Research: A valuable compound for studying spirocyclic chemistry and developing new synthetic methodologies.

Basic Information

Item	Detail
Product Name	Spiro[3H-Indole-3,3-Pyrrolidin]-2(1H)-One, 2-Ethyl-, (2R,3R)-Rel- (9Ci)
CAS No.	676447-78-2
Molecular Formula	C14H16N2O
Molecular Weight	228.29 g/mol
Synonyms	rel-(2R,3R)-2-Ethylspiro[3H-indole-3,3'-pyrrolidin]-2'(1'H)-one; (2R,3R)-2-Ethyl-1,2-dihydrospiro[3H-indole-3,3'-pyrrolidine]-2'-one; 676447-78-2; Spiro[indole-3,3'-pyrrolidine]-2'-one, 2-ethyl-, (2R,3R)-rel-; (rel-(2R,3R))-2-Ethyl-1,2-dihydrospiro[3H-indole-3,3'-pyrrolidine]-2'-one; A chiral spirocyclic indolinone.
EINECS	Contact for details

Quality Control

Our Spiro[3H-Indole-3,3-Pyrrolidin]-2(1H)-One, 2-Ethyl-, (2R,3R)-Rel- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with exacting research and pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider using an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.