Description

1H-Indole-1-Acetonitrile, 3-(Hydroxymethyl)- is a versatile indole-based nitrile derivative, a crucial building block in advanced organic synthesis. Its molecular structure, featuring both a reactive nitrile group and a hydroxymethyl substituent, makes it a valuable precursor for constructing complex heterocyclic compounds and active pharmaceutical ingredients (APIs). This high-purity intermediate is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new therapeutic agents and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel indole-based drug candidates, including potential kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Research: Serves as a precursor for developing new generation pesticides and herbicides with specific biological activity.
• Fine Chemical Synthesis: Used in the preparation of complex molecules for material science, including ligands for catalysis and advanced polymers.
• Bioconjugation & Probe Development: The functional groups allow for its use in creating fluorescent probes or biochemical tags for diagnostic applications.
• Academic & Contract Research: A valuable reagent for methodological development and exploratory chemistry in university and CRO laboratories.

Basic Information

Product Name	1H-Indole-1-Acetonitrile, 3-(Hydroxymethyl)-
CAS No.	675841-97-1
Molecular Formula	C11H10N2O
Molecular Weight	186.21 g/mol
Synonyms	3-(Hydroxymethyl)-1H-indole-1-acetonitrile; 1H-Indole-1-acetonitrile, 3-(hydroxymethyl)-; 3-(Hydroxymethyl)indole-1-acetonitrile; (3-Hydroxymethyl-1H-indol-1-yl)acetonitrile; 1-Cyanomethyl-3-hydroxymethylindole; 3-Hydroxymethyl-1-cyanomethylindole
EINECS	Contact for details

Quality Control

Our 1H-Indole-1-Acetonitrile, 3-(Hydroxymethyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for prolonged storage to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.