Description

(+/-)-7-Hydroxy-1,2,3,4-Tetrahydro-3-Isoquinoline-4-Carboxylic Acid Methyl Ester Hcl is a high-purity, synthetic organic compound belonging to the tetrahydroisoquinoline class, serving as a critical chiral building block and intermediate in advanced chemical synthesis. Its value lies in its functionalized structure, which provides a versatile scaffold for constructing complex molecules with potential biological activity. This product is essential for research and development chemists in the pharmaceutical and fine chemical industries, particularly those focused on medicinal chemistry, process development, and the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries and exploring structure-activity relationships (SAR) in drug discovery programs.
• Process Chemistry: Serves as a critical intermediate in the scale-up and optimization of synthetic routes for complex organic molecules.
• Fine Chemical Synthesis: Employed in the production of specialty chemicals, advanced materials, and other high-value tetrahydroisoquinoline derivatives.
• Academic & Institutional Research: Utilized in universities and research institutes for studies in organic synthesis, asymmetric catalysis, and chemical biology.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	(+/-)-7-Hydroxy-1,2,3,4-Tetrahydro-3-Isoquinoline-4-Carboxylic Acid Methyl Ester Hcl
CAS No.	672310-19-9
Molecular Formula	C12H15NO3 • HCl
Molecular Weight	257.71 g/mol (Free base: 221.25 g/mol)
Synonyms	Methyl 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-4-carboxylate hydrochloride; (±)-7-Hydroxy-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid methyl ester hydrochloride; 7-Hydroxy-Tic-Ome hydrochloride; 4-Carbomethoxy-7-hydroxy-1,2,3,4-tetrahydroisoquinoline HCl; 672310-19-9; Methyl 4,7-dihydroxy-3,4-dihydroisoquinoline-3-carboxylate hydrochloride (tautomeric form); 7-Hydroxy-D-Tic-Ome hydrochloride (referring to one enantiomer series).
EINECS	Contact for details

Quality Control

Our (+/-)-7-Hydroxy-1,2,3,4-Tetrahydro-3-Isoquinoline-4-Carboxylic Acid Methyl Ester Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR, MS) to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment. We can support development projects requiring compliance with ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual unknown impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.