Description

Bicyclo[3.1.0]Hexane-2-Acetic Acid, 2-(Aminomethyl)-6,6-Dimethyl-, (1R,2S,5S)-Rel- (9Ci) is a high-purity, stereochemically defined bicyclic amino acid derivative, serving as a critical chiral building block and advanced pharmaceutical intermediate. Its unique constrained structure is essential for synthesizing complex molecules with specific three-dimensional architectures, directly impacting the efficacy and selectivity of final active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in areas requiring sophisticated molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, especially in central nervous system (CNS) and antiviral research.
• Peptidomimetics & Constrained Peptide Design: Used to introduce rigid, bicyclic motifs into peptide backbones to enhance metabolic stability and receptor binding affinity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for developing novel chiral ligands and organocatalysts.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new chemical space and optimize lead compounds.
• Chemical Biology Probes: Incorporated into molecular probes to study enzyme mechanisms and protein-protein interactions due to its defined stereochemistry.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring high-fidelity chiral building blocks.

Basic Information

Product Name	Bicyclo[3.1.0]Hexane-2-Acetic Acid, 2-(Aminomethyl)-6,6-Dimethyl-, (1R,2S,5S)-Rel- (9Ci)
CAS No.	663178-22-1
Molecular Formula	C11H19NO2
Molecular Weight	197.27 g/mol
Synonyms	(1R,2S,5S)-rel-2-(Aminomethyl)-6,6-dimethylbicyclo[3.1.0]hexane-2-acetic acid; (1R,2S,5S)-2-(Aminomethyl)-6,6-dimethylbicyclo[3.1.0]hexane-2-acetic acid; Bicyclo[3.1.0]hexane-2-acetic acid, 2-(aminomethyl)-6,6-dimethyl-, (1R,2S,5S)-rel-; 663178-22-1; rel-(1R,2S,5S)-2-(Aminomethyl)-6,6-dimethylbicyclo[3.1.0]hexane-2-acetic acid; Bicyclo[3.1.0]hexane-2-acetic acid, 2-(aminomethyl)-6,6-dimethyl-, (1R,2S,5S)-; A constrained bicyclic β-amino acid derivative.
EINECS	Contact for details

Quality Control

Our Bicyclo[3.1.0]Hexane-2-Acetic Acid, 2-(Aminomethyl)-6,6-Dimethyl-, (1R,2S,5S)-Rel- (9Ci) is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for specified isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.