Description

Alvimopan-D5 (Mixture Of Diastereomers) is a deuterium-labeled analog of the peripherally acting mu-opioid receptor antagonist, alvimopan. This stable isotope-labeled compound is a critical reference material for quantitative bioanalytical studies, ensuring accurate and reliable pharmacokinetic and metabolic data. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and academic institutions engaged in advanced drug metabolism and pharmacokinetics (DMPK) research.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a crucial internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods for the precise quantification of alvimopan in complex biological matrices such as plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Used in absorption, distribution, metabolism, and excretion (ADME) studies to track the parent drug and elucidate metabolic pathways without isotopic interference.
• Pharmacokinetic (PK) Profiling: Enables accurate PK modeling by providing a stable isotope-labeled reference that co-elutes with the analyte, correcting for matrix effects and instrument variability.
• Bioequivalence and Clinical Trial Support: Essential for developing validated bioanalytical assays required for clinical trials and bioequivalence studies of alvimopan formulations.
• Quality Control in Reference Standard Production: Acts as a system suitability check and a calibrant in the quality control of unlabeled alvimopan reference standards.

Basic Information

Product Name	Alvimopan-D5 (Mixture Of Diastereomers)
CAS No.	660848-76-0
Molecular Formula	C25H27D5N2O4
Molecular Weight	Approx. 424.55 g/mol
Synonyms	LY-246736-D5; (2S)-2-[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]acetamide-D5; ADL 8-2698-D5; Entereg-D5; Alvimopan (phenyl-D5); Deuterated Alvimopan; Alvimopan-d5; [[(2S)-2-[[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]acetyl]amino]acetic acid-d5]
EINECS	Contact for details

Quality Control

Our Alvimopan-D5 is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided, detailing specifications for isotopic enrichment (D, atom %), chemical purity, and diastereomeric ratio. Our quality system is designed to support GLP and GMP-regulated research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F). Due to its hygroscopic nature, the product should be stored in a dry environment. For long-term storage, consider desiccant in the container. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D, atom %)	≥ 98.0%
Diastereomeric Ratio (HPLC)	Specified on COA
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.