Description

5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde is a high-purity, advanced pharmaceutical intermediate and agrochemical building block. This compound is valued for its unique pyrazole core, which is functionalized with chloro, difluoromethyl, and aldehyde groups, making it a versatile synthon for constructing complex bioactive molecules. It is primarily sought by R&D and production teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Serves as a critical precursor for developing new-generation fungicides and insecticides, leveraging the bioactivity of the difluoromethylpyrazole moiety.
• Chemical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of proprietary compounds under cGMP conditions.
• Material Science: Potential use as a monomer or functionalizing agent in the development of specialty polymers and advanced materials.

Basic Information

Product Name	5-Chloro-3-(Difluoromethyl)-1-Methyl-1H-Pyrazole-4-Carbaldehyde
CAS No.	660845-30-7
Molecular Formula	C6H5ClF2N2O
Molecular Weight	194.57 g/mol
Synonyms	5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxaldehyde; 4-Formyl-5-chloro-3-(difluoromethyl)-1-methylpyrazole; 5-Chloro-3-difluoromethyl-1-methyl-1H-pyrazole-4-carbaldehyde; 660845-30-7; 5-Chloro-3-(difluoromethyl)-1-methylpyrazole-4-carbaldehyde
EINECS	Contact for details

Quality Control

We supply 5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde in various purity grades suitable for research and commercial scale applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles as confirmed by HPLC, GC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0% (Standard Grade)
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.