Description

2-Thiophenecarboxamide,5-Methyl-n-[(1R,2S)-2-Phenylcyclopropyl]-,Rel- CAS NO 658684-08-3 is a high-purity, stereochemically defined organic compound featuring a thiophene carboxamide core linked to a chiral phenylcyclopropyl moiety. This compound matters as a sophisticated chiral building block and intermediate, critical for the research and development of novel active pharmaceutical ingredients (APIs) and advanced materials. It is primarily needed by pharmaceutical R&D teams, agrochemical innovators, and specialty chemical manufacturers focused on creating enantiomerically pure products with specific biological or material properties.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of potential drug candidates, particularly in central nervous system (CNS) and metabolic disorder research.
• Agrochemical Research: Used in the development of new, more selective pesticides and herbicides, leveraging its unique thiophene-based structure.
• Ligand & Catalyst Development: Acts as a precursor or framework for creating novel chiral ligands and organocatalysts for asymmetric synthesis.
• Material Science: Investigated as a monomer or functional additive for specialty polymers and organic electronic materials due to the thiophene unit.
• Chemical Biology Probe: Utilized in academic and industrial research to study enzyme inhibition or receptor binding mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds for client-specific discovery programs.

Basic Information

Product Name	2-Thiophenecarboxamide,5-Methyl-n-[(1R,2S)-2-Phenylcyclopropyl]-,Rel- CAS NO 658684-08-3
CAS No.	658684-08-3
Molecular Formula	C15H15NOS
Molecular Weight	257.35 g/mol
Synonyms	rel-(1R,2S)-N-(2-Phenylcyclopropyl)-5-methylthiophene-2-carboxamide; (1R,2S)-N-(2-Phenylcyclopropyl)-5-methyl-2-thiophenecarboxamide (rel); 5-Methyl-N-[(1R,2S)-2-phenylcyclopropyl]thiophene-2-carboxamide (rel); 658684-08-3; Thiophene-2-carboxamide, 5-methyl-N-[(1R,2S)-2-phenylcyclopropyl]-, rel-; Chiral Thiophene Amide Intermediate; Phenylcyclopropyl Thiophene Carboxamide
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure high chemical and enantiomeric purity suitable for sensitive R&D applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (diastereomeric excess)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.