Description

4-Bromo-1-Oxo-1,3-Dihydro-Isoindole-2-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its brominated isoindole core and tert-butyl ester protecting group. This compound is of critical importance for enabling complex synthetic routes in medicinal chemistry, particularly for the development of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the synthesis of targeted small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug candidates, especially those targeting neurological and oncological pathways.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker or warhead component in the design of novel heterobifunctional degraders.
• Kinase Inhibitor Synthesis: Used in constructing isoindolinone-based scaffolds for potential kinase inhibitors due to its rigid, planar structure.
• Chemical Biology Research: Employed as a molecular probe or a tagged precursor for studying protein-ligand interactions and cellular processes.
• Agrochemical Intermediate: Potential use in the research and development of new agrochemicals with specific bioactivity.
• Material Science Precursor: Can be utilized in the synthesis of specialized organic materials and functional polymers.

Basic Information

Product Name	4-Bromo-1-Oxo-1,3-Dihydro-Isoindole-2-Carboxylic Acid tert-Butyl Ester
CAS No.	658683-18-2
Molecular Formula	C₁₃H₁₄BrNO₃
Molecular Weight	312.16 g/mol
Synonyms	tert-Butyl 4-bromo-1-oxo-1,3-dihydro-2H-isoindole-2-carboxylate; 4-Bromo-1-oxoisoindoline-2-carboxylic acid tert-butyl ester; 2H-Isoindole-2-carboxylic acid, 4-bromo-1,3-dihydro-1-oxo-, 1,1-dimethylethyl ester; 4-Bromo-1-oxo-1,3-dihydroisoindole-2-carboxylic acid tert-butyl ester; 4-Bromoisoindoline-1-one-2-carboxylic acid tert-butyl ester; BOC-4-Bromo-isoindolinone; 658683-18-2
EINECS	Contact for details

Quality Control

Our production of 4-Bromo-1-Oxo-1,3-Dihydro-Isoindole-2-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical R&D. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.