Description

4-(Chloromethyl)-5-(Difluoromethoxy)-1-Methyl-3-(Trifluoromethyl)-1H-Pyrazole CAS NO 656825-76-2 is a high-value, multi-functional pyrazole derivative characterized by its unique halogenated and fluorinated substituents. This compound serves as a critical advanced pharmaceutical intermediate and key building block in the synthesis of complex active ingredients. It is primarily required by R&D and production teams in the agrochemical and pharmaceutical industries for developing novel compounds with enhanced biological activity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system and metabolic disorders.
• Agrochemical Synthesis: Serves as a crucial precursor for developing next-generation herbicides, insecticides, and fungicides, leveraging the difluoromethoxy and trifluoromethyl groups for improved efficacy and environmental profile.
• Chemical Research & Development: Used as a versatile building block in medicinal chemistry and material science for introducing fluorinated motifs, which can alter lipophilicity, metabolic stability, and binding affinity.
• Ligand and Catalyst Development: The pyrazole core can be utilized to create novel ligands for catalysis or functional materials.
• Custom Synthesis Projects: Supplied for contract research and manufacturing projects requiring specific, high-purity fluorinated heterocycles.

Basic Information

Product Name	4-(Chloromethyl)-5-(Difluoromethoxy)-1-Methyl-3-(Trifluoromethyl)-1H-Pyrazole
CAS No.	656825-76-2
Molecular Formula	C8H6ClF5N2O
Molecular Weight	276.59 g/mol
Synonyms	1-Methyl-3-(trifluoromethyl)-4-(chloromethyl)-5-(difluoromethoxy)-1H-pyrazole; 4-(Chloromethyl)-5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)pyrazole; 1H-Pyrazole, 4-(chloromethyl)-5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-; 656825-76-2; 4-Chloromethyl-5-difluoromethoxy-1-methyl-3-trifluoromethyl-1H-pyrazole
EINECS	Contact for details

Quality Control

Our production of 4-(Chloromethyl)-5-(Difluoromethoxy)-1-Methyl-3-(Trifluoromethyl)-1H-Pyrazole adheres to stringent ISO 9001 quality management principles. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to the presence of reactive functional groups, it is recommended to store under an inert atmosphere for long-term stability and to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.