Description

tert-Butyl 2-(Methoxymethyl)Indoline-1-Carboxylate is a high-value, protected indoline derivative used as a key synthetic intermediate in advanced organic chemistry. Its primary commercial value lies in enabling the efficient construction of complex nitrogen-containing heterocycles, which are crucial scaffolds in modern pharmaceuticals. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require a reliable, high-purity building block for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging the indoline core for biological activity.
• Fine Chemical Production: Serves as a versatile precursor for creating complex, high-value specialty chemicals and catalysts.
• Academic & Contract Research: A valuable reagent for method development and exploring new synthetic routes in academic laboratories and CROs (Contract Research Organizations).
• Peptidomimetics & PROTACs: The protected amine and ester functionalities make it suitable for constructing peptidomimetic compounds and Proteolysis-Targeting Chimeras (PROTACs).

Basic Information

Product Name	tert-Butyl 2-(Methoxymethyl)Indoline-1-Carboxylate
CAS No.	656257-05-5
Molecular Formula	C15H21NO3
Molecular Weight	263.33 g/mol
Synonyms	1-Boc-2-(methoxymethyl)indoline; 1-(tert-Butoxycarbonyl)-2-(methoxymethyl)indoline; tert-Butyl 2-(methoxymethyl)-2,3-dihydro-1H-indole-1-carboxylate; 2,3-Dihydro-2-(methoxymethyl)-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester; 1H-Indole-1-carboxylic acid, 2,3-dihydro-2-(methoxymethyl)-, 1,1-dimethylethyl ester; Boc-2-(methoxymethyl)indoline; 656257-05-5
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(Methoxymethyl)Indoline-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. All products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.