Description

(1R,5S,7R)-tert-Butyl 7-Hydroxy-3-Oxa-9-Azabicyclo[3.3.1]Nonane-9-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex, rigid bicyclic scaffold. This compound is a critical chiral building block for the synthesis of sophisticated active pharmaceutical ingredients (APIs), particularly in neurological and antiviral therapeutic areas. It is essential for research and development chemists and process scale-up teams in the pharmaceutical and fine chemical industries who require a reliable source of high-quality, stereochemically defined intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug molecules, particularly those targeting the central nervous system.
• Neurological Drug Development: Used in research and production of potential therapeutics for conditions such as Parkinson's disease, Alzheimer's disease, and neuropathic pain.
• Antiviral Agent Synthesis: Serves as a precursor in the development of novel antiviral compounds due to its constrained molecular architecture.
• Medicinal Chemistry Research: Provides a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Process Chemistry & Scale-Up: Supplied in development and commercial quantities to support route optimization and cGMP manufacturing campaigns.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in stereoselective transformations to introduce complex chirality.

Basic Information

Product Name	(1R,5S,7R)-tert-Butyl 7-Hydroxy-3-Oxa-9-Azabicyclo[3.3.1]Nonane-9-Carboxylate
CAS No.	652148-14-6
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	9-Boc-7-hydroxy-3-oxa-9-azabicyclo[3.3.1]nonane; tert-Butyl 7-hydroxy-3-oxa-9-azabicyclo[3.3.1]nonane-9-carboxylate; (1R,5S,7R)-9-(tert-Butoxycarbonyl)-7-hydroxy-3-oxa-9-azabicyclo[3.3.1]nonane; 3-Oxa-9-azabicyclo[3.3.1]nonane-9-carboxylic acid, 7-hydroxy-, 1,1-dimethylethyl ester, (1R,5S,7R)-; Bicyclic amino alcohol Boc derivative
EINECS	Contact for details

Quality Control

Our (1R,5S,7R)-tert-Butyl 7-Hydroxy-3-Oxa-9-Azabicyclo[3.3.1]Nonane-9-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high stereochemical purity and chemical identity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep the container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.