Description

1-(5-Bromo-3-Methyl-1H-Indazol-1-Yl)-Ethanone is a high-purity, advanced pharmaceutical intermediate characterized by its brominated indazole core structure. This compound is of significant value in medicinal chemistry for its role as a versatile building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of targeted therapeutics, particularly in oncology and other disease areas.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Research: Serves as a critical scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Organic Synthesis Building Block: Used in cross-coupling reactions and other transformations to introduce the functionalized indazole moiety into more complex molecular architectures.
• Biochemical Tool Compound: Potential use in the development of biochemical probes for studying enzyme function and cellular pathways.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects.

Basic Information

Product Name	1-(5-Bromo-3-Methyl-1H-Indazol-1-Yl)-Ethanone
CAS No.	651780-46-0
Molecular Formula	C10H9BrN2O
Molecular Weight	253.10 g/mol
Synonyms	1-(5-Bromo-3-methyl-1H-indazol-1-yl)ethanone; 1-Acetyl-5-bromo-3-methyl-1H-indazole; 5-Bromo-3-methyl-1H-indazol-1-yl ethyl ketone; 5-Bromo-3-methyl-1-acetylindazole; Ethanone, 1-(5-bromo-3-methyl-1H-indazol-1-yl)-; 651780-46-0; 1-(5-Bromo-3-methylindazol-1-yl)ethanone
EINECS	Contact for details

Quality Control

Our production of 1-(5-Bromo-3-Methyl-1H-Indazol-1-Yl)-Ethanone adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical research and development applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques (HPLC, GC, NMR, MS) to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment, supporting your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 20 ppm
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.