Description

2,5,8,11,14,17,20,23,26,29-Decaoxahentriacontane-31-Thiol (CAS 651042-85-2) is a specialized polyethylene glycol (PEG) derivative functionalized with a terminal thiol (-SH) group, making it a valuable heterobifunctional linker for advanced material science and bioconjugation. This compound is engineered to provide a hydrophilic spacer arm with a reactive thiol moiety, enabling the formation of stable thioether bonds with maleimides, iodoacetamides, or other electrophiles under mild conditions. It is essential for researchers and manufacturers in nanotechnology, biopharmaceutical development, and surface functionalization who require precise, water-soluble crosslinking strategies.

Application

• Bioconjugation and PEGylation: Used as a heterobifunctional crosslinker to attach proteins, peptides, or antibodies to nanoparticles, surfaces, or other biomolecules via thiol-maleimide chemistry.
• Surface Modification and Self-Assembled Monolayers (SAMs): The thiol group allows for covalent attachment to gold, silver, or other metal surfaces, creating hydrophilic, protein-resistant, or biofunctional coatings.
• Nanoparticle Functionalization: Critical for stabilizing quantum dots, liposomes, and polymeric nanoparticles by providing a hydrophilic PEG shell and a functional handle for further coupling of targeting ligands.
• Hydrogel Formation: Acts as a crosslinking agent in the synthesis of hydrogels for drug delivery systems and tissue engineering scaffolds.
• Sensor Development: Employed in the fabrication of biosensors and diagnostic devices to immobilize biorecognition elements onto transducer surfaces.
• Polymer Chemistry: Serves as a chain transfer agent (CTA) or functional initiator in controlled radical polymerization (e.g., RAFT) to synthesize telechelic or block copolymers.
• Chromatography and Affinity Media: Used to modify stationary phases or resins to create hydrophilic interaction chromatography (HILIC) materials or affinity ligands.

Basic Information

Item	Details
Product Name	2,5,8,11,14,17,20,23,26,29-Decaoxahentriacontane-31-Thiol
CAS No.	651042-85-2
Molecular Formula	C₂₁H₄₄O₁₀S
Molecular Weight	500.64 g/mol
Synonyms	α-Mercapto-ω-methoxy-undeca(ethylene glycol); HS-PEG₁₁-OMe; 11-Mercapto-3,6,9,12,15,18,21,24,27,30-decaoxadotriacontan-32-ol, 32-methoxy-; Methoxy-PEG₁₁-thiol; mPEG₁₁-SH; PEG-Thiol (MW ~500); Heterobifunctional PEG, Thiol-PEG-Methoxy; Thiol-terminated methoxy polyethylene glycol
EINECS	Contact for details

Quality Control

Our 2,5,8,11,14,17,20,23,26,29-Decaoxahentriacontane-31-Thiol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance for sensitive applications like bioconjugation. Key parameters verified include purity (by HPLC/NMR), thiol content titration, and the absence of peroxides and heavy metals. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) at 2-8°C. The material is easily oxidized; avoid exposure to air and moisture. Allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (Thiol Titration)	≥ 90% of theoretical
Water Content (KF)	≤ 1.0%
Peroxide Value	≤ 0.5 meq/kg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.