Description

2,5,8,11,14,17,20,23,26-Nonaoxaoctacosane-28-Thiol is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a terminal thiol (-SH) group. This compound is engineered to serve as a versatile heterobifunctional linker, enabling the conjugation of biomolecules, polymers, and surfaces through thiol-based click chemistry. It is essential for researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors who require precise and stable cross-linking capabilities.

Application

• Bioconjugation and PEGylation: Used to attach therapeutic proteins, peptides, or antibodies to drug delivery systems (e.g., liposomes, nanoparticles) to enhance solubility, stability, and circulation time.
• Surface Functionalization: Acts as a self-assembled monolayer (SAM) precursor on gold, silver, or other metal surfaces for biosensor and diagnostic device development.
• Polymer Chemistry: Serves as a chain transfer agent (CTA) or functional initiator in controlled radical polymerization (e.g., RAFT) to synthesize telechelic or block copolymers.
• Hydrogel Formation: Utilized as a cross-linking agent via thiol-ene or thiol-Michael addition reactions to create tunable, biocompatible hydrogel networks for tissue engineering.
• Nanoparticle Stabilization and Targeting: Conjugated to the surface of quantum dots or metallic nanoparticles to provide colloidal stability and enable further attachment of targeting ligands.
• Chromatography Media: Immobilized onto solid supports (e.g., agarose, silica) to create affinity chromatography resins for protein purification.

Basic Information

Product Name	2,5,8,11,14,17,20,23,26-Nonaoxaoctacosane-28-Thiol
CAS No.	651042-84-1
Molecular Formula	C₂₀H₄₂O₉S
Molecular Weight	482.61 g/mol
Synonyms	mPEG9-SH; α-Methyl-ω-mercapto-nona(ethylene glycol); HS-PEG9-OMe; 1-Mercapto-2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-one (related); Methoxy-PEG9-thiol; PEG9 methyl ether thiol; Thiol-PEG9-OMe; 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosane-1-thiol (alternative numbering)
EINECS	Contact for details

Quality Control

Every batch of our 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosane-28-Thiol is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from NMR, HPLC, and titration methods. Our production adheres to cGMP principles where applicable, supporting its use in research and development for regulated industries.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) at 2-8°C. The material is easily oxidized; therefore, containers should be flushed with inert gas after each opening to minimize degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (Thiol Titration)	≥ 90.0%
Water Content (KF)	≤ 1.0%
Molecular Weight (NMR)	460 - 500 g/mol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.