Description

2,5,8,11,14,17,20,23-Octaoxapentacosane-25-Thiol is a specialized polyethylene glycol (PEG) derivative featuring a terminal thiol (-SH) functional group, also known by its CAS number 651042-83-0. This compound is valued for its ability to act as a versatile linker or surface modifier, enabling the creation of stable, biocompatible coatings and conjugates. It is primarily sought by manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors for applications requiring precise molecular attachment and controlled surface properties.

Application

• Bioconjugation and Protein/Peptide Modification: Used to attach PEG chains (PEGylation) to therapeutic proteins, peptides, or antibodies to enhance solubility, stability, and circulation time.
• Surface Functionalization for Biosensors: Serves as a self-assembled monolayer (SAM) on gold or other metal surfaces to create bio-inert, functionalizable platforms for diagnostic assays and sensor development.
• Nanoparticle and Quantum Dot Capping: Acts as a stabilizing ligand to passivate the surface of nanoparticles and quantum dots, improving colloidal stability and providing sites for further bioconjugation.
• Hydrogel and Polymer Network Formation: Utilized as a crosslinking agent in thiol-ene "click" chemistry reactions to form hydrogels and polymer networks for drug delivery and tissue engineering.
• Microarray and Chip Fabrication: Enables the precise, covalent immobilization of biomolecules onto solid supports for high-throughput screening and genomic/proteomic analysis.
• Gold Nanoparticle (AuNP) Synthesis and Stabilization: Commonly employed in the synthesis and functionalization of gold nanoparticles due to the strong Au-S bond.

Basic Information

Product Name	2,5,8,11,14,17,20,23-Octaoxapentacosane-25-Thiol
CAS No.	651042-83-0
Molecular Formula	C17H36O8S
Molecular Weight	400.53 g/mol
Synonyms	mPEG8-Thiol; α-Methoxy-ω-mercapto octa(ethylene glycol); HS-PEG8-OMe; 1-Mercapto-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-ol, 27-methoxy-; 8-Arm PEG Thiol; O-(2-Mercaptoethyl) O'-methyloctaethylene glycol; Thiol-PEG8-OMe; PEG8 methyl ether thiol
EINECS	Contact for details

Quality Control

Our 2,5,8,11,14,17,20,23-Octaoxapentacosane-25-Thiol is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Quality is verified through analytical techniques including NMR, HPLC, and titration to confirm structure, purity, and functional group integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties of being easily oxidized (store under inert atmosphere) and highly volatile, it is recommended to store the material under an inert gas (argon or nitrogen) at 2-8°C for long-term stability. Allow the sealed container to reach room temperature before opening to minimize moisture ingress and oxidation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Thiol Content (Titration)	≥ 90% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.