Description

2,5,8,11,14,17,20-Heptaoxadocosane-22-Thiol is a specialized polyethylene glycol (PEG) derivative featuring a terminal thiol (-SH) functional group. This compound is valued for its ability to act as a heterobifunctional linker, enabling the conjugation of biomolecules, polymers, and surfaces through thiol-reactive chemistry. It is essential for researchers and manufacturers in the biotechnology, pharmaceutical, and advanced materials sectors who require precise surface modification, protein PEGylation, or the creation of functional hydrogels and nanoparticles.

Application

• Bioconjugation and Protein PEGylation: Used to attach polyethylene glycol chains to proteins, peptides, or antibodies to improve solubility, stability, and circulation time.
• Surface Functionalization: Employed to create self-assembled monolayers (SAMs) on gold, silver, or other metal surfaces for biosensor and diagnostic device development.
• Polymer Chemistry and Cross-linking: Serves as a chain transfer agent in RAFT polymerization or as a cross-linker for synthesizing hydrogels and polymer networks with tailored properties.
• Nanoparticle and Quantum Dot Capping: Provides a stabilizing, biocompatible coating on nanoparticles and quantum dots for biomedical imaging and drug delivery applications.
• Material Science: Utilized to modify the surface properties of polymers, glass, or other materials to introduce specific chemical functionalities.
• Diagnostic Reagent Synthesis: A key intermediate in the production of labeled probes, assay components, and other diagnostic reagents.

Basic Information

Product Name	2,5,8,11,14,17,20-Heptaoxadocosane-22-Thiol
CAS No.	651042-82-9
Molecular Formula	C15H32O7S
Molecular Weight	356.48 g/mol
Synonyms	mPEG7-Thiol; α-Methyl-ω-mercapto hepta(ethylene glycol); HS-PEG7-OCH3; 1-Mercapto-3,6,9,12,15,18,21-heptaoxatetratriacontan-24-one (related); Heptaethylene glycol monomethyl ether thiol; 22-Mercapto-2,5,8,11,14,17,20-heptaoxadocosane; PEG7-Thiol; Thiol-PEG7-OMe
EINECS	Contact for details

Quality Control

Every batch of 2,5,8,11,14,17,20-Heptaoxadocosane-22-Thiol is produced and tested under strict quality management protocols. We ensure high purity and lot-to-lot consistency through comprehensive analytical techniques, including NMR, HPLC, and titration for thiol content. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and specification compliance.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation of the thiol group. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Thiol Content (Titration)	≥ 90% of theoretical
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.