Description

(S)-((R)-1-(4-(4-Fluoro-2-Methyl-1H-Indol-5-Yloxy)-5-Methylpyrrolo[2,1-F][1,2,4]Triazin-6-Yloxy)Propan-2-Yl) 2-(Benzyloxycarbonylamino)Propanoate is a sophisticated, high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound matters because it serves as a critical building block for the development of targeted therapeutic agents, particularly in oncology and other specialized drug discovery pipelines. Pharmaceutical R&D teams and advanced fine chemical manufacturers need this precise molecule to enable the synthesis of complex active pharmaceutical ingredients (APIs) with high stereochemical fidelity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel small-molecule drug candidates.
• Oncology Drug Discovery: Used in the synthesis of targeted cancer therapies, leveraging its specific indole and triazine-based structure.
• Preclinical & Clinical Trial Material: Serves as a critical raw material for producing batches of investigational new drugs for non-clinical and clinical studies.
• Process Chemistry & Route Scouting: Employed by process chemists to develop and optimize scalable synthetic routes for new chemical entities.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific advanced intermediates.
• Academic & Institutional Research: Utilized in university and institutional labs for medicinal chemistry programs and biochemical probe development.

Basic Information

Product Name	(S)-((R)-1-(4-(4-Fluoro-2-Methyl-1H-Indol-5-Yloxy)-5-Methylpyrrolo[2,1-F][1,2,4]Triazin-6-Yloxy)Propan-2-Yl) 2-(Benzyloxycarbonylamino)Propanoate
CAS No.	649736-41-4
Molecular Formula	C31H32FN5O6
Molecular Weight	589.62 g/mol
Synonyms	N-CBZ-L-Alanine, (1R)-1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanyl ester, (S)-; (S)-2-(((Benzyloxy)carbonyl)amino)propanoic acid (1R)-1-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)oxy)propan-2-yl ester; 649736-41-4; Z-L-Ala-OC(CH3)2CH2O-Pyrrolotriazine derivative; CBZ-L-Alanine Pyrrolotriazine Ester; Advanced Pharmaceutical Intermediate 649736-41-4
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, chiral HPLC, 1H/13C NMR, and mass spectrometry to confirm identity, purity, and enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications. We support compliance with cGMP standards for materials intended for use in drug substance manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.