Description

2-(4-(4-Fluoro-2-Methyl-1H-Indol-5-Yloxy)-5-Methylpyrrolo[1,2-F][1,2,4]Triazin-6-Yl)Propan-2-Ol is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is critical for the synthesis of targeted therapeutic agents, offering precise molecular functionality for research and development. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel small-molecule drugs, particularly in oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for targeted cancer therapies.
• Biochemical Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Preclinical Development: Essential for producing compounds for pharmacological profiling, toxicology studies, and formulation development.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and cGMP production.
• Academic Research: Utilized in university and institutional labs for exploring new chemical entities and biological pathways.

Basic Information

Item	Details
Product Name	2-(4-(4-Fluoro-2-Methyl-1H-Indol-5-Yloxy)-5-Methylpyrrolo[1,2-F][1,2,4]Triazin-6-Yl)Propan-2-Ol
CAS No.	649736-30-1
Molecular Formula	C19H19FN4O2
Molecular Weight	354.38 g/mol
Synonyms	5-((6-(2-Hydroxypropan-2-yl)-5-methylpyrrolo[1,2-f][1,2,4]triazin-4-yl)oxy)-4-fluoro-2-methyl-1H-indole; 2-[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yl]propan-2-ol; UNII-5V6K3G4Y0W; 5V6K3G4Y0W; Intermediate for TAK-285; Pyrrolotriazine derivative
EINECS	Contact for details

Quality Control

Every batch of 2-(4-(4-Fluoro-2-Methyl-1H-Indol-5-Yloxy)-5-Methylpyrrolo[1,2-F][1,2,4]Triazin-6-Yl)Propan-2-Ol is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure high purity and batch-to-batch consistency suitable for research and development applications. Comprehensive Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.