Description

1-Isoquinolineacetic Acid,1,2,3,4-Tetrahydro-6-Hydroxy-,Ethyl Ester is a specialized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key chiral intermediate in the development of complex, biologically active molecules. Pharmaceutical researchers and fine chemical manufacturers need it for the synthesis of potential drug candidates, particularly in neurological and cardiovascular research areas.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs).
• Neurological Research: Used in the synthesis of compounds targeting central nervous system (CNS) disorders.
• Cardiovascular Drug Development: Serves as a building block for molecules with potential vasodilatory or receptor-modulating activity.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions to introduce the tetrahydroisoquinoline scaffold.
• Medicinal Chemistry: A versatile precursor for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Fine Chemical Production: Used in the custom synthesis of high-value, low-volume specialty chemicals for research and development.

Basic Information

Product Name	1-Isoquinolineacetic Acid,1,2,3,4-Tetrahydro-6-Hydroxy-,Ethyl Ester
CAS No.	649722-04-3
Molecular Formula	C₁₃H₁₇NO₃
Molecular Weight	235.28 g/mol
Synonyms	Ethyl 1,2,3,4-Tetrahydro-6-hydroxy-1-isoquinolineacetate; 6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-acetic Acid Ethyl Ester; (1,2,3,4-Tetrahydro-6-hydroxy-1-isoquinolinyl)acetic Acid Ethyl Ester; THIQ Derivative; Tetrahydroisoquinoline Ethyl Ester; Chiral IHQ Building Block; CAS 649722-04-3
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for research and development. Quality is verified through comprehensive analytical techniques including HPLC, GC, and NMR. A Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (ee)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.