Description

2-Thiophenecarboxylic Acid, 4-Bromo-5-Formyl-, Methyl Ester is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, featuring both bromo and formyl substituents on the thiophene ring, which provide distinct reactive handles for constructing complex molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the thiophene scaffold's bioactivity.
• Material Science Precursor: Serves as a monomer or building block for conductive polymers, organic semiconductors, and non-linear optical (NLO) materials.
• Ligand Synthesis: The formyl and ester groups allow for the creation of complex chelating ligands used in catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and fluorescent tags for studying biological processes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthetic routes and scale-up projects.

Basic Information

Product Name	2-Thiophenecarboxylic Acid, 4-Bromo-5-Formyl-, Methyl Ester
CAS No.	648412-59-3
Molecular Formula	C8H5BrO3S
Molecular Weight	261.09 g/mol
Synonyms	Methyl 4-Bromo-5-formyl-2-thiophenecarboxylate; 4-Bromo-5-formyl-2-thiophenecarboxylic Acid Methyl Ester; 2-Thiophenecarboxylic acid, 4-bromo-5-formyl-, methyl ester; Methyl 4-bromo-5-formylthiophene-2-carboxylate; 4-Bromo-5-formylthiophene-2-carboxylic acid methyl ester; 5-Formyl-4-bromothiophene-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 2-Thiophenecarboxylic Acid, 4-Bromo-5-Formyl-, Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP and ISO guidelines ensures a reliable supply for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.