Description

(5α)-4,5-Epoxy-3,14-Dihydroxy-17-(2-Propenyl)-Morphinan-6-One Cyclic 1,2-Ethanediyl Acetal is a high-purity, specialized morphinan derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate or reference standard for the synthesis and analytical characterization of novel therapeutic agents targeting the central nervous system. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in medicinal chemistry and pharmacology.

Application

• Pharmaceutical Intermediate: A key building block in the synthetic pathway for novel opioid receptor modulators and other neuroactive compounds.
• Reference Standard: Used for method development, validation, and quality control in analytical laboratories (HPLC, LC-MS) to ensure product purity and identity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new chemical entities with potential analgesic or other neurological effects.
• Biochemical Research: Utilized as a ligand in receptor binding assays and other in vitro studies to investigate mechanisms of action.
• Process Development: Serves as a standard for scaling up and optimizing synthetic routes in pilot plants and manufacturing settings.
• Impurity Profiling: Acts as a characterized impurity or degradation product standard for regulatory filing and stability testing of active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	(5α)-4,5-Epoxy-3,14-Dihydroxy-17-(2-Propenyl)-Morphinan-6-One Cyclic 1,2-Ethanediyl Acetal
CAS No.	646032-89-5
Molecular Formula	C24H27NO6
Molecular Weight	425.48 g/mol
Synonyms	Oxycodone Impurity K; 14-Hydroxycodeinone cyclic 1,2-ethanediyl acetal; 14-Hydroxy-7,8-dihydrocodeinone cyclic ethylene acetal; 4,5α-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one cyclic 1,2-ethanediyl acetal; Noroxycodone ethylene ketal derivative; (5α)-4,5-Epoxy-3,14-dihydroxy-17-(prop-2-en-1-yl)morphinan-6-one cyclic ethylene acetal
EINECS	Contact for details

Quality Control

Our (5α)-4,5-Epoxy-3,14-Dihydroxy-17-(2-Propenyl)-Morphinan-6-One Cyclic 1,2-Ethanediyl Acetal is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your regulatory and quality needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment to prevent degradation. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.