Description

tert-Butyl 7-Amino-4,4-Dimethyl-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is a high-purity, protected amine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in pharmaceutical research and development. It is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially within therapeutic areas requiring sophisticated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, particularly those with isoquinoline-based structures.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization for discovering novel therapeutics.
• Process Chemistry: Serves as a building block in the scalable synthesis of target molecules during process research and development (PR&D).
• Chemical Biology: Employed in the synthesis of molecular probes and tool compounds for studying biological pathways and target validation.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Academic Research: Utilized in university and institutional labs for methodological development and the synthesis of novel chemical entities.

Basic Information

Product Name	tert-Butyl 7-Amino-4,4-Dimethyl-3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	645418-66-2
Molecular Formula	C16H24N2O2
Molecular Weight	276.38 g/mol
Synonyms	7-Amino-1,2,3,4-tetrahydro-4,4-dimethylisoquinoline-2-carboxylic acid tert-butyl ester; tert-Butyl 7-amino-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; 2(1H)-Isoquinolinecarboxylic acid, 7-amino-3,4-dihydro-4,4-dimethyl-, 1,1-dimethylethyl ester; 7-Amino-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; BOC-7-Amino-4,4-DMTIQ; BOC-protected 7-amino-4,4-dimethyl-TIQ
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Amino-4,4-Dimethyl-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.