Description

2’-o-Methyl-Pyrrolo C Cep is a high-purity, modified nucleoside analog used as a critical building block in advanced oligonucleotide synthesis. This compound matters for its role in enhancing the stability and specificity of therapeutic nucleic acids, such as antisense oligonucleotides and siRNA. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and CDMOs engaged in the development of next-generation genetic medicines and molecular diagnostics.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified RNA and DNA strands.
• Antisense Therapeutics: Used in the research and production of antisense oligonucleotides (ASOs) designed for targeted gene silencing.
• siRNA Development: Incorporated into small interfering RNA (siRNA) constructs to improve nuclease resistance and pharmacokinetic profiles.
• Diagnostic Probe Design: Serves as a modified base in high-specificity probes for molecular diagnostics and research assays.
• Apitamer Research: Employed in the synthesis of chemically modified aptamers for therapeutic and sensing applications.
• Academic & Industrial R&D: A vital reagent for universities and biotech firms exploring novel nucleic acid chemistries and drug modalities.

Basic Information

Product Name	2’-o-Methyl-Pyrrolo C Cep
CAS No.	644962-95-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	2'-O-Methylpyrrolocytidine CEP; 2'-O-Methyl-pyrrolo-C CEP; 1-(2-O-Methyl-β-D-ribofuranosyl)-4-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2-pyrrolocytosine; Pyrrolo-C CEP 2'-O-Methyl derivative; 2'-OMe-Pyrrolo-C CEP; N4-Acetyl-2'-O-methyl-5-(1-propynyl)cytidine CEP; 2'-O-Methyl-5-(1-propynyl)cytidine CEP; 2'-O-Methyl-pyrrolocytidine phosphoramidite
EINECS	Contact for details

Quality Control

Every batch of 2’-o-Methyl-Pyrrolo C Cep is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high-purity standards required for oligonucleotide synthesis. Our quality commitment includes comprehensive characterization by HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and moisture content is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and light-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.