Description

Benzene, [(1R,2S)-2-(1,1-Dimethylethoxy)cyclopropyl]-, rel- (9Ci) is a high-purity, stereochemically defined chiral building block essential for advanced organic synthesis. This compound matters as a key intermediate in the development of complex, biologically active molecules, offering precise structural control for pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug discovery programs.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides where specific stereochemistry is crucial for biological activity and environmental profile.
• Ligand and Catalyst Precursor: Serves as a starting material for the preparation of chiral ligands and organometallic catalysts used in asymmetric synthesis.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex natural products, flavors, and fragrances requiring high stereochemical fidelity.
• Material Science Research: Potential building block for advanced organic materials, such as liquid crystals or polymers with specific chiral properties.

Basic Information

Item	Details
Product Name	Benzene, [(1R,2S)-2-(1,1-Dimethylethoxy)cyclopropyl]-, rel- (9Ci)
CAS No.	642075-95-4
Molecular Formula	C14H20O
Molecular Weight	204.31 g/mol
Synonyms	rel-[(1R,2S)-2-(tert-Butoxy)cyclopropyl]benzene; 1-[(1R,2S)-2-(tert-Butoxy)cyclopropyl]benzene; Benzene, [(1R,2S)-2-(1,1-dimethylethoxy)cyclopropyl]-, rel-; (rel-(1R,2S)-2-(tert-Butoxy)cyclopropyl)benzene; tert-Butyl (1R,2S)-2-phenylcyclopropyl ether (relative configuration); Chiral Cyclopropane Benzene Derivative; (1R,2S)-2-(tert-Butoxy)-1-phenylcyclopropane (rel)
EINECS	Contact for details

Quality Control

Our Benzene, [(1R,2S)-2-(1,1-Dimethylethoxy)cyclopropyl]-, rel- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% de (diastereomeric excess)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.