Description

tert-Butyl 3-Iodo-7-Methoxy-1H-Indazole-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its functionalized indazole core. This compound is of significant value for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries seeking to develop new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting kinase inhibition and other biological pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its reactive iodine and protected amine functionalities.
• Process Chemistry Development: Serves as a critical starting material for scaling up the production of target molecules under Good Manufacturing Practice (GMP) conditions.
• Bioconjugation & Probe Synthesis: The iodine moiety allows for further functionalization via cross-coupling reactions, useful for creating labeled compounds for biological assays.
• Agrochemical Research: Potential application as an intermediate in the development of new crop protection agents with novel modes of action.

Basic Information

Product Name	tert-Butyl 3-Iodo-7-Methoxy-1H-Indazole-1-Carboxylate
CAS No.	639084-05-2
Molecular Formula	C13H15IN2O3
Molecular Weight	374.18 g/mol
Synonyms	1-Boc-3-iodo-7-methoxy-1H-indazole; tert-Butyl 3-iodo-7-methoxyindazole-1-carboxylate; 3-Iodo-7-methoxy-1H-indazole-1-carboxylic acid tert-butyl ester; 1H-Indazole-1-carboxylic acid, 3-iodo-7-methoxy-, 1,1-dimethylethyl ester; 639084-05-2; Boc-3-I-7-MeO-indazole
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Iodo-7-Methoxy-1H-Indazole-1-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality management system supports compliance with cGMP and ICH Q7 guidelines for active pharmaceutical ingredients (APIs) and intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.