Description

tert-Butyl 5-Chlorospiro[Indoline-3,4'-Piperidine]-1'-Carboxylate is a high-value, complex heterocyclic building block featuring a spirocyclic indoline-piperidine core. This compound is of significant interest for its role as a key synthetic intermediate in modern pharmaceutical research and development. It is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing novel drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting complex receptors.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) around the spirocyclic scaffold.
• Library Synthesis: Serves as a versatile core structure for generating diverse compound libraries in high-throughput screening for new drug discovery.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the commercial manufacturing of advanced drug candidates.
• Biochemical Tool Compound: Can be utilized to develop probes for studying biological pathways and target validation in preclinical research.

Basic Information

Product Name	tert-Butyl 5-Chlorospiro[Indoline-3,4'-Piperidine]-1'-Carboxylate
CAS No.	637362-21-1
Molecular Formula	C17H23ClN2O2
Molecular Weight	322.83 g/mol
Synonyms	1'-Boc-5-Chlorospiro[indoline-3,4'-piperidine]; 5-Chloro-1'-Boc-spiro[indoline-3,4'-piperidine]; tert-Butyl 5-chloro-2,3-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate; 5-Chlorospiro[indoline-3,4'-piperidine]-1'-carboxylic acid tert-butyl ester; 1'-Boc-5-chlorospiro[indoline-3,4'-piperidine]; 637362-21-1; 5-Chloro-1'-(tert-butoxycarbonyl)spiro[indoline-3,4'-piperidine]
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Chlorospiro[Indoline-3,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.