Description

(1S,3R,5R)-tert-Butyl 3-(tert-Butoxycarbonyl)-6-Oxa-Bicyclo[3.1.0]Hexane-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex, rigid bicyclic scaffold. This compound is valued for its role as a critical building block in the synthesis of novel, stereochemically defined active pharmaceutical ingredients (APIs). It is primarily sought after by research and development teams and process chemists in the pharmaceutical and biotechnology industries for the development of new therapeutic agents, particularly in areas requiring sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders and antiviral applications.
• Organic Synthesis Building Block: Utilized in medicinal chemistry for constructing constrained analogs and probing structure-activity relationships (SAR) due to its fused oxa-bicyclo[3.1.0]hexane core.
• Process Chemistry & Scale-Up: Serves as a critical starting material or intermediate in route development and optimization for Good Manufacturing Practice (GMP) production.
• Asymmetric Synthesis: Its defined (1S,3R,5R) stereochemistry makes it invaluable for introducing multiple chiral centers in a controlled manner in target molecules.
• Academic & Industrial Research: Used in chemical biology and methodology development for creating novel compound libraries and exploring new chemical spaces.

Basic Information

Product Name	(1S,3R,5R)-tert-Butyl 3-(tert-Butoxycarbonyl)-6-Oxa-Bicyclo[3.1.0]Hexane-3-Carboxylate
CAS No.	635318-02-4
Molecular Formula	C15H24O5
Molecular Weight	284.35 g/mol
Synonyms	(1S,3R,5R)-3-(tert-Butoxycarbonyl)-6-oxabicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester; tert-Butyl (1S,3R,5R)-3-(tert-butoxycarbonyl)-6-oxabicyclo[3.1.0]hexane-3-carboxylate; (1S,3R,5R)-6-Oxabicyclo[3.1.0]hexane-3-carboxylic acid, 3-(1,1-dimethylethoxy)carbonyl-, 1,1-dimethylethyl ester; Bicyclo[3.1.0]hexane-3-carboxylic acid derivative; Chiral Oxa-Bicyclo Intermediate; CAS 635318-02-4
EINECS	Contact for details

Quality Control

Our production of (1S,3R,5R)-tert-Butyl 3-(tert-Butoxycarbonyl)-6-Oxa-Bicyclo[3.1.0]Hexane-3-Carboxylate adheres to stringent quality management protocols. Each batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure high chemical and stereochemical purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.