Description

1H-Indole-1-Carboxylic Acid, 3-(1-Cyano-1-Methylethyl)-6-[Methyl(Phenylmethyl)Amino]-, 1,1-Dimethylethyl Ester is a specialized indole derivative, a crucial advanced intermediate in modern pharmaceutical synthesis. This compound matters for its role as a key building block in the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. Pharmaceutical R&D and process chemistry teams need this high-purity intermediate to streamline their synthetic routes and accelerate drug development pipelines.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Active Pharmaceutical Ingredient (API) Development: Used in the research and process development stages for creating novel therapeutic compounds.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis and scale-up projects.
• Biochemical Research: Potential use as a probe or inhibitor in biochemical assays studying specific enzymatic pathways.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of other high-value, complex organic molecules.

Basic Information

Product Name	1H-Indole-1-Carboxylic Acid, 3-(1-Cyano-1-Methylethyl)-6-[Methyl(Phenylmethyl)Amino]-, 1,1-Dimethylethyl Ester
CAS No.	629662-57-3
Molecular Formula	C25H29N3O2
Molecular Weight	403.52 g/mol
Synonyms	tert-Butyl 3-(1-cyano-1-methylethyl)-6-[methyl(benzyl)amino]-1H-indole-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-(1-cyano-1-methylethyl)-6-[N-methyl-N-(phenylmethyl)amino]indole; 6-[Benzyl(methyl)amino]-3-(1-cyano-1-methylethyl)-1H-indole-1-carboxylic Acid tert-Butyl Ester; 3-(2-Cyano-2-propyl)-6-[N-benzyl-N-methylamino]-1H-indole-1-carboxylic Acid tert-Butyl Ester; 629662-57-3; Boc-Protected Indole Intermediate; N-Boc-3-(α-cyanoisopropyl)-6-(N-benzyl-N-methylamino)indole
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality control protocols include rigorous analytical testing via HPLC, GC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support our partners in meeting the stringent requirements of cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions or an inert atmosphere to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.