Description

(1S,3R)-1-Benzo[1,3]Dioxol-5-Yl-2-(2-Chloro-Acetyl)-2,3,4,9-Tetrahydro-1H-B-Carboline-3-Carboxylic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant value for its role as a key synthetic building block in the research and development of novel therapeutic agents. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex alkaloid derivatives and drug candidates.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, particularly those targeting neurological and oncological pathways.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs) within the β-carboline alkaloid class.
• Process Chemistry Development: Used in scaling up and optimizing synthetic routes for active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Academic & Institutional Research: Utilized in university and institutional labs for studying heterocyclic chemistry, reaction mechanisms, and the biological activity of complex organic molecules.

Basic Information

Item	Detail
Product Name	(1S,3R)-1-Benzo[1,3]Dioxol-5-Yl-2-(2-Chloro-Acetyl)-2,3,4,9-Tetrahydro-1H-B-Carboline-3-Carboxylic Acid Methyl Ester
CAS No.	629652-40-0
Molecular Formula	C22H19ClN2O5
Molecular Weight	426.85 g/mol
Synonyms	Methyl (1S,3R)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylate; (1S,3R)-1-(Benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester; 1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester, (1S,3R)-; β-Carboline derivative 629652-40-0; Tetrahydro-β-carboline ester intermediate
EINECS	Contact for details

Quality Control

Our (1S,3R)-1-Benzo[1,3]Dioxol-5-Yl-2-(2-Chloro-Acetyl)-2,3,4,9-Tetrahydro-1H-B-Carboline-3-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.