Description

(1,2,3,4-Tetrahydro-Isoquinolin-1-Yl)-Acetonitrile Hydrochloride is a versatile and high-purity chemical intermediate, primarily valued for its role in the synthesis of complex pharmaceutical compounds. Its structural framework makes it a critical building block for medicinal chemistry research and development, enabling the creation of novel therapeutic agents. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking reliable, high-quality synthetic precursors.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular drug candidates.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic molecules.
• Process Chemistry & Scale-Up: Serves as a critical starting material or intermediate in the development and optimization of commercial-scale synthetic routes.
• Agrochemical Synthesis: Employed in the research and production of advanced pesticides and herbicides.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals, dyes, and other complex organic compounds.
• Academic & Institutional R&D: Supports chemical biology and synthetic methodology research in university and government laboratories.

Basic Information

Product Name	(1,2,3,4-Tetrahydro-Isoquinolin-1-Yl)-Acetonitrile Hydrochloride
CAS No.	627098-24-2
Molecular Formula	C11H13ClN2
Molecular Weight	208.69 g/mol
Synonyms	1-(Cyanomethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride; 2-[(1,2,3,4-Tetrahydro-1-isoquinolinyl)]acetonitrile hydrochloride; (1,2,3,4-Tetrahydroisoquinolin-1-yl)acetonitrile HCl; 1,2,3,4-Tetrahydro-1-isoquinolineacetonitrile hydrochloride; Tetrahydroisoquinolineacetonitrile hydrochloride; TIQA hydrochloride; THIQ-acetonitrile HCl
EINECS	Contact for details

Quality Control

Our (1,2,3,4-Tetrahydro-Isoquinolin-1-Yl)-Acetonitrile Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring a reliable supply for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent absorption of atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.