Description

Isoquinoline, 1,2,3,4-Tetrahydro-5-Iodo-2-(Trifluoroacetyl)-7-(Trifluoromethyl)- is a highly functionalized, fluorinated isoquinoline derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its complex structure, featuring iodine and trifluoromethyl groups, makes it a valuable building block for constructing sophisticated molecules with tailored properties. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science: Building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its unique electronic properties imparted by the halogen and fluorine substituents.
• Chemical Biology & Probe Development: Serves as a scaffold for creating fluorescent probes, enzyme inhibitors, and other tools for biochemical and diagnostic research.
• Catalyst & Ligand Synthesis: Intermediate for the preparation of complex nitrogen-containing ligands used in asymmetric catalysis and transition metal complexes.
• Academic & Contract Research: Essential for methodological studies in organic synthesis, including cross-coupling reactions and fluorination chemistry.

Basic Information

Product Name	Isoquinoline, 1,2,3,4-Tetrahydro-5-Iodo-2-(Trifluoroacetyl)-7-(Trifluoromethyl)-
CAS No.	625126-88-7
Molecular Formula	C13H8F6INO
Molecular Weight	443.11 g/mol
Synonyms	5-Iodo-2-(trifluoroacetyl)-7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline; 7-(Trifluoromethyl)-5-iodo-1,2,3,4-tetrahydroisoquinoline-2-(trifluoroacetamide); 1,2,3,4-Tetrahydro-7-(trifluoromethyl)-5-iodoisoquinoline-2-carboxylic acid trifluoroacetate (derivative); TFAI-THIQ; Iodo-trifluoroacetyl-tetrahydroisoquinoline derivative
EINECS	Contact for details

Quality Control

Every batch of Isoquinoline, 1,2,3,4-Tetrahydro-5-Iodo-2-(Trifluororoacetyl)-7-(Trifluoromethyl)- is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing batch-specific results are provided with each shipment. We support development and commercial projects requiring material that meets stringent internal specifications for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to maximize stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.