Description

7-(Trifluoromethyl)-1,2,3,4-Tetrahydro-5-Nitroisoquinoline Hydrochloride is a high-purity, advanced pharmaceutical intermediate and research chemical. This compound is valued for its unique trifluoromethyl and nitro-substituted isoquinoline scaffold, which is critical for modulating the biological activity and pharmacokinetic properties of target molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of the trifluoromethyl and nitro groups on potency, selectivity, and metabolic stability.
• Process Chemistry Development: Employed in route scouting, optimization, and scale-up activities for the production of active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Acts as a precursor for developing molecular probes to study enzyme function or receptor interactions in biological systems.
• Agrochemical Research: Investigated as an intermediate for novel crop protection agents, leveraging the bioactivity of its heterocyclic core.

Basic Information

Product Name	7-(Trifluoromethyl)-1,2,3,4-Tetrahydro-5-Nitroisoquinoline Hydrochloride
CAS No.	625126-83-2
Molecular Formula	C₁₀H₁₀F₃N₃O₂·HCl
Molecular Weight	297.66 g/mol (Free base)
Synonyms	5-Nitro-7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride; 7-(Trifluoromethyl)-5-nitro-1,2,3,4-tetrahydroisoquinoline HCl; 1,2,3,4-Tetrahydro-7-(trifluoromethyl)-5-nitroisoquinoline hydrochloride; 5-Nitro-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline hydrochloride; 625126-83-2 (CAS); 7-Trifluoromethyl-5-nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride salt
EINECS	Contact for details

Quality Control

Our 7-(Trifluoromethyl)-1,2,3,4-Tetrahydro-5-Nitroisoquinoline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.