Description

(S)-Amino-(1-Methyl-1H-Indol-3-Yl)-Acetic Acid is a high-purity, non-natural amino acid derivative featuring a chiral center and a substituted indole moiety. This compound is a critical chiral building block for the synthesis of complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug candidates.
• Peptidomimetics & Drug Design: Used to incorporate the unique indole-acetic acid structure into peptide backbones to enhance binding affinity, metabolic stability, and bioavailability.
• Asymmetric Synthesis: Serves as a chiral precursor or auxiliary in stereoselective chemical reactions to construct complex molecules with high enantiomeric purity.
• Bioconjugation & Probe Development: Employed in the creation of biochemical probes and labeled compounds for diagnostic and research applications.
• Chemical Biology Research: Utilized as a tool compound to study enzyme-substrate interactions and biological pathways involving amino acid metabolism.
• Custom Synthesis & Contract Manufacturing: Supplied for custom synthesis projects requiring specific, high-value chiral intermediates under cGMP or research-grade conditions.

Basic Information

Item	Detail
Product Name	(S)-Amino-(1-Methyl-1H-Indol-3-Yl)-Acetic Acid
CAS No.	623582-99-0
Molecular Formula	C₁₁H₁₂N₂O₂
Molecular Weight	204.23 g/mol
Synonyms	(S)-2-Amino-2-(1-methyl-1H-indol-3-yl)acetic acid; (S)-α-Amino-(1-methylindol-3-yl)acetic acid; (S)-1-Methyl-3-(aminomethyl)indole-3-acetic acid; (S)-AMIA; (S)-Indole-3-glycine derivative; (S)-3-(1-Methyl-1H-indol-3-yl)glycine; (S)-2-Amino-2-(1-methylindol-3-yl)ethanoic acid
EINECS	Contact for details

Quality Control

Our (S)-Amino-(1-Methyl-1H-Indol-3-Yl)-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity (HPLC), chemical purity (HPLC), and identity confirmation (NMR, IR, MS). We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.