Description

n-Boc-6-Bromomethyl-1,2,3,4-Tetrahydroisoquinoline is a high-purity, protected heterocyclic building block of significant importance in modern organic synthesis. This compound is valued for its reactive bromomethyl group and the versatile N-Boc protecting group, which allows for selective functionalization under mild conditions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the construction of complex molecular architectures, including active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of tetrahydroisoquinoline-based drug candidates, including potential central nervous system (CNS) agents and anticancer compounds.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Alkaloid Synthesis: Used in the construction of complex natural product analogs and alkaloid derivatives for biological evaluation.
• Peptidomimetics: Employed to introduce rigid, aromatic elements into peptide backbones to enhance stability and bioavailability.
• Agrochemical Development: Acts as a building block for novel herbicides, fungicides, and plant growth regulators.
• Material Science: Potential monomer or cross-linking agent for the development of specialty polymers with unique properties.

Basic Information

Product Name	n-Boc-6-Bromomethyl-1,2,3,4-Tetrahydroisoquinoline
CAS No.	622867-53-2
Molecular Formula	C₁₅H₂₀BrNO₂
Molecular Weight	326.23 g/mol
Synonyms	1,2,3,4-Tetrahydro-6-(bromomethyl)isoquinoline-2-carboxylic acid tert-butyl ester; tert-Butyl 6-(bromomethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate; 6-Bromomethyl-1,2,3,4-tetrahydroisoquinoline N-Boc derivative; Boc-6-Bromomethyl-THIQ; N-Boc-6-(Bromomethyl)-1,2,3,4-tetrahydroisoquinoline; 2-(tert-Butoxycarbonyl)-6-(bromomethyl)-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our n-Boc-6-Bromomethyl-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.