Description

tert-Butyl 6-(Hydroxymethyl)-3,4-Dihydroisoquinoline-2(1H)-Carboxylate CAS NO 622867-52-1 is a high-purity, protected heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in providing a versatile scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of tetrahydroisoquinoline-based drug candidates, including potential central nervous system (CNS) agents, anticancer compounds, and enzyme inhibitors.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing focused libraries and exploring structure-activity relationships (SAR) in drug discovery programs.
• Process Chemistry Development: Used in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) requiring the dihydroisoquinoline core.
• Agrochemical Synthesis: Intermediate for developing novel pesticides and herbicides that incorporate nitrogen-containing heterocycles.
• Fine Chemical Production: Employed in the custom synthesis of specialty chemicals, catalysts, and ligands for asymmetric synthesis.
• Academic & Institutional Research: A valuable reagent for methodological studies in organic synthesis and heterocyclic chemistry at universities and research institutes.

Basic Information

Product Name	tert-Butyl 6-(Hydroxymethyl)-3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	622867-52-1
Molecular Formula	C15H21NO3
Molecular Weight	263.33 g/mol
Synonyms	2(1H)-Isoquinolinecarboxylic acid, 6-(hydroxymethyl)-3,4-dihydro-, 1,1-dimethylethyl ester; 1,1-Dimethylethyl 6-(hydroxymethyl)-3,4-dihydro-2(1H)-isoquinolinecarboxylate; tert-Butyl 6-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; Boc-6-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline; 6-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; TB-6-HM-THIQ; Boc-THIQ(6-CH2OH)
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-(Hydroxymethyl)-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.