Description

1-(3-Chloro-4-Fluorophenyl)-3-(Thiophen-2-Yl)-1H-Pyrazole-5-Carboxylic Acid is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular architecture, which combines halogenated phenyl, thiophene, and pyrazole-carboxylic acid moieties, making it a versatile precursor for creating complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, as well as by material scientists exploring new functional polymers and electronic materials.

Application

• Pharmaceutical Intermediate: Serves as a critical scaffold in the research and development of new drug candidates, particularly for kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used as a key building block for creating novel herbicides, fungicides, and insecticides, leveraging its halogenated and heterocyclic structure for bioactivity.
• Material Science Research: Acts as a monomer or functional component in the development of advanced polymers, liquid crystals, and organic semiconductors for electronic applications.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A pivotal starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards for client-specific molecules.

Basic Information

Product Name	1-(3-Chloro-4-Fluorophenyl)-3-(Thiophen-2-Yl)-1H-Pyrazole-5-Carboxylic Acid
CAS No.	618382-87-9
Molecular Formula	C14H8ClFN2O2S
Molecular Weight	322.74 g/mol
Synonyms	1-(3-Chloro-4-fluorophenyl)-3-(thiophen-2-yl)-1H-pyrazole-5-carboxylic acid; 3-(Thiophen-2-yl)-1-(3-chloro-4-fluorophenyl)-1H-pyrazole-5-carboxylic acid; 1H-Pyrazole-5-carboxylic acid, 1-(3-chloro-4-fluorophenyl)-3-(2-thienyl)-; 618382-87-9; 1-(3-Chloro-4-fluorophenyl)-3-(thien-2-yl)-1H-pyrazole-5-carboxylic acid; 1-(3-Chloro-4-fluorophenyl)-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-(3-Chloro-4-Fluorophenyl)-3-(Thiophen-2-Yl)-1H-Pyrazole-5-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and industrial use. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every batch upon request, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.