Description

1-(2,4-Difluorophenyl)-3-Phenyl-1H-Pyrazole-5-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its pyrazole-carboxylic acid core with fluorinated aromatic substituents. This compound is critical for the synthesis of active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas, offering a key building block for medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and agrochemical companies seeking to develop novel small-molecule drugs or crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in therapeutic areas requiring fluorinated heterocycles for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Serves as a building block for developing new-generation pesticides and herbicides, where the difluorophenyl and pyrazole motifs contribute to biological activity.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical entities.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for producing specialized, high-value compounds.
• Biochemical Tool Compound: Potential use in developing probes or inhibitors for biological target validation in research settings.

Basic Information

Product Name	1-(2,4-Difluorophenyl)-3-Phenyl-1H-Pyrazole-5-Carboxylic Acid
CAS No.	618101-96-5
Molecular Formula	C₁₆H₁₀F₂N₂O₂
Molecular Weight	300.26 g/mol
Synonyms	5-Carboxy-1-(2,4-difluorophenyl)-3-phenyl-1H-pyrazole; 1H-Pyrazole-5-carboxylic acid, 1-(2,4-difluorophenyl)-3-phenyl-; 618101-96-5; 1-(2,4-Difluorophenyl)-3-phenyl-1H-pyrazole-5-carboxylic acid; 3-Phenyl-1-(2,4-difluorophenyl)-1H-pyrazole-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 1-(2,4-Difluorophenyl)-3-Phenyl-1H-Pyrazole-5-Carboxylic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) standards for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.